Paget's disease Paget's disease of bone is a chronic (long-term) condition that affects bone growth, causing bones to expand and become deformed. The deformed bones then become weaker and are more likely to fracture (break). The areas of the body affected most often are the spine, the pelvis, the legs, the skull (head) and the collarbone. Paget's disease of bone is more common in the UK than in anywhere else in the world. It tends to affect people over the age of 40 and there are more cases in men than in women. Paget's disease of bone is not the same as paget's disease of the breast and genitals, which is a type of skin cancer. Glossary Deformed Deformity is used to describe a part of the body that is not the usual shape. This could develop during pregnancy or as a result of a condition or inj Spine The spine supports the skeleton, and surrounds and protects the delicate spinal cord and nerves. It is made up of 33 bones called the vertebrae. Chronic Chronic usually means a condition that continues for a long time or keeps coming back